Biomedical Engineering

The research on Bioengineering is directed at studying the human body using dry and wet materials, sensing and actuation and intelligent wetware, software and hardware. the main research topics include Computational Physiology, Computer Assisted Surgery and Augmented Reality, Deisgn of Non Animal Testing Systems,Biomedical imaging, Wearable Biomedical Sensors and Systems, Biomedical Additive Manufacturing.

The Research in Biomedical Engineering is carried on in collaboration with the Research Center of the University of Pisa "E.Piaggio".

 

Computational Physiology & Biomedical Instruments 

The research activities of the Computational Physiology & Biomedical Instruments group are focused on the investigation physiological and pathophysiological dynamics through advanced bioengineering systems and signal processing methods. Applications include the assessment of autonomic nervous system activity on cardiovascular control, brain-heart interaction, affective computing, human-horse interaction, and  assessment of mood and mental/neurological disorders. The group is also active in devising ad-hoc cutting-edge, advanced biomedical signal processing and artificial intelligence techniques, allowing for the application of machine learning algorithms to clinical and psychological assessments.

 

Computer Assisted Surgery and Augmented Reality

 

Design of Non Animal Testing Systems

Investigation of integrative physiology in-vitro and in-silico through the development and study of physiologically relevant models of organs and multi-organ systems. 

 

Biomedical imaging

Cell imaging: The non-invasive monitoring of tissue engineered constructs in an environment that closely mimics in vivoconditions is one of the main challenges in regenerative medicine. In fact, the ability to visualize cells seeded on a scaffold can help elucidate cell/biomaterial interactions without sacrificing samples. In addition, monitoring the micro-environment in terms of both biochemical (i.e. the distribution of O2) and biophysical (i.e. scaffold stiffness or shear stress induced by flux) stimuli can be useful in the development of disease models as well as in the study of the cell response to drugs or toxic materials.

 

Wearable Biomedical Sensors and Systems

Wearable technologies- such as sensor embedded garments, are changing our lives becoming exoprostheses, able to augment our perception of reality with physical, social and emotional content. The areas of application of our research span from fashion and leisure, healthcare and emergency.

 

Biomedical additive manufacturing

Biological tissues have highly complex and functional architectures. In order to construct engineered tissue with a high degree of complexity, cells must be provided with a suitable three dimensional synthetic or biological scaffolds upon which they can adhere and proliferate. Advanced fabrication technologies are combined, including 3D printing, for creating scaffolds, in-vitro models, biosensors and actuators using smart and biomaterials. Applications are mainly focused on Tissue Engineering, regenerative medicine and biotechnologies. The integration of 2D and 3D technologies are essential for fabricating complex structures using different material (including living cells) at different scales, from nanometers up to centimeters.